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Understanding OTC Decongestants: Safety and Effectiveness

October 4, 2025

Introduction to OTC Decongestants

Over-the-counter (OTC) decongestants can provide short-term relief from nasal congestion, especially during acute upper respiratory infections (URIs). Common options include pseudoephedrine and phenylephrine, both offering varying levels of effectiveness in alleviating congestion.

Effectiveness of Pseudoephedrine vs. Phenylephrine

Among these OTC decongestants, studies indicate that pseudoephedrine is generally more effective than phenylephrine for relieving nasal congestion. It’s crucial to consider the specific needs and medical history of the patient when choosing between these medications.

Safety Considerations and Usage Guidelines

While OTC decongestants can be beneficial, their use should be limited to a duration of 3 to 5 days to prevent rebound congestion. They are not recommended for children under 4 years old or for pregnant individuals. Additionally, patients with hypertension, cardiovascular conditions, or other significant health issues should use these medications with caution or avoid them entirely. Understanding these safety limits is essential for effective and responsible use of OTC decongestants.

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